The metabolism of pantothenic acid.

نویسنده

  • G M BROWN
چکیده

The formulation of this pathway was based on: (a) the finding that cysteine supplies the sulfur-containing moiety of CoA (3,4); (b) the activities of pantetheine and pantothenylcysteine as growth factors for Acetobacter suboxydans (4-6) and Lactobacillus helveticus (7); (c) the presence of enzymes in these two organisms and also in Lactobacillus bulgur&s which decarboxylate pantothenylcysteine to pantetheine (4, 7); (d) the report by Hoagland and Novelli (8) that rat liver extracts are able to convert pantothenylcysteine to CoA; and (e) the discovery, separation, and partial purification of the enzymes which convert pantetheine to CoA (8, 9). It has been reported that 4’-P-pantothenic acid may be synthesized from pantothenic acid and ATP by enzymes present in Lactobacillus arabinosus (10) and Proteus morganii (11). These reports led Ward et a2. (11) to postulate the existence of an alternate route of CoA synthesis which might operate in certain microorganisms and which would include P-pantothenic acid, P-pantothenylcysteine, and P-pantetheine as intermediates. The results of the present investigations establish the existence of such a pathway in both mammalian and microbial systems, and, moreover, indicate that in rat liver and some microorganisms it appears to be the only route by which CoA is synthesized.

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عنوان ژورنال:
  • The Journal of biological chemistry

دوره 234 2  شماره 

صفحات  -

تاریخ انتشار 1959