The metabolism of pantothenic acid.
نویسنده
چکیده
The formulation of this pathway was based on: (a) the finding that cysteine supplies the sulfur-containing moiety of CoA (3,4); (b) the activities of pantetheine and pantothenylcysteine as growth factors for Acetobacter suboxydans (4-6) and Lactobacillus helveticus (7); (c) the presence of enzymes in these two organisms and also in Lactobacillus bulgur&s which decarboxylate pantothenylcysteine to pantetheine (4, 7); (d) the report by Hoagland and Novelli (8) that rat liver extracts are able to convert pantothenylcysteine to CoA; and (e) the discovery, separation, and partial purification of the enzymes which convert pantetheine to CoA (8, 9). It has been reported that 4’-P-pantothenic acid may be synthesized from pantothenic acid and ATP by enzymes present in Lactobacillus arabinosus (10) and Proteus morganii (11). These reports led Ward et a2. (11) to postulate the existence of an alternate route of CoA synthesis which might operate in certain microorganisms and which would include P-pantothenic acid, P-pantothenylcysteine, and P-pantetheine as intermediates. The results of the present investigations establish the existence of such a pathway in both mammalian and microbial systems, and, moreover, indicate that in rat liver and some microorganisms it appears to be the only route by which CoA is synthesized.
منابع مشابه
Effect of in ovo Injection of Nicotonic Acid, Pantothenic Acid or Folic Acid on Immune System and Growth of Broiler Chickens
BACKGROUND: In ovo injection of nutrients as an early feeding method in birds directly supplies the nu- trients to the developing embryo. OBJECTIVES: This study was designed to evaluate the effects of in ovo injection of nicotonic acid, panto- thenic acid and folic acid on the performance and immune system of broilers. METHODS: </st...
متن کاملThe metabolism in vitro of cardiac muscle in pantothenic acid deficiency.
An important r81e for pantothenic acid in carbohydrate metabolism was suggested by studies in which pantothenic acid-deficient bacteria (1, 2) and liver (3) were observed to utilize pyruvate at rates much less than normal. The subsequent discovery of Lipmann and his colleagues that the coenzyme of acetylation (coenzyme A) (4) contained pantothenic acid (5) provided a stimulus for the reinvestig...
متن کاملEffects of excess pantothenic acid administration on the other water-soluble vitamin metabolisms in rats.
To acquire the data concerning the tolerable upper intake level which prevents health problems from an excessive intake of pantothenic acid, an animal experiment was done. Rats of the Wistar strain (male, 3 wk old) were fed on a diet which contains 0%, 0.0016% (control group), 1%, or 3% calcium pantothenate for 29 d. The amount of weight increase, the food intake, and the organ weights were mea...
متن کاملDifferent variations of tissue B-group vitamin concentrations in short- and long-term starved rats.
Prolonged starvation changes energy metabolism; therefore, the metabolic response to starvation is divided into three phases according to changes in glucose, lipid and protein utilisation. B-group vitamins are involved in energy metabolism via metabolism of carbohydrates, fatty acids and amino acids. To determine how changes in energy metabolism alter B-group vitamin concentrations during starv...
متن کاملB-vitamin Nutrition in Dairy Cows
The B-vitamins include thiamin (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), the B6 complex (pyridoxal, pyridoxamine, pyridoxine), biotin (B8 or Vitamin H), folic acid (B9), and B12. Each of the B-vitamins plays a key role as either an enzymatic cofactor or metabolic constituent in many facets of intermediary metabolism. For example, about half of the propionate that reaches the ru...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of biological chemistry
دوره 234 2 شماره
صفحات -
تاریخ انتشار 1959